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Scientific News Media Demonstrates an Affinity for ERX-41

Following the publication of the article “Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress” in Nature Cancer, from the lab of etiraRx co-founder Ganesh Raj, scientific news media was quick to pick up on this major breakthrough in cancer research. In the paper, ERX-41 demonstrates “a large therapeutic window, with no adverse effects either on normal mammary epithelial cells or in mice,” potentially providing a route to treating previously untreatable solid cancers, such as triple-negative breast cancer.

A selection of the news articles which have picked up on the story are below.

EurekAlert!: Promising compound kills range of hard-to-treat cancers by targeting a previously undiscovered vulnerability
Yahoo!: EtiraRx’s Licensed ERX-41 Identified as a Potential New Oral Therapy for Multiple Cancers, Company Prepares for Clinical Trials
KAIT-TV: EtiraRx’s Licensed ERX-41 Identified as a Potential New Oral Therapy for Multiple Cancers, Company Prepares for Clinical Trials
News-medical.net: New compound shows promise to kill a range of hard-to-treat cancer types
News-medical.net: New molecule kills a broad spectrum of hard-to-treat cancers
Good News Network: Protein Destroys ‘Hard to Treat’ Cancers, Could Become ‘One Size Fits All’ Pill
Interesting Engineering: Scientists discovered a new molecule that kills even the deadliest cancer
MedicalXpress: Promising compound kills range of hard-to-treat cancers by targeting a previously undiscovered vulnerability
Bioengineer.org: Promising compound kills range of hard-to-treat cancers by targeting a previously undiscovered vulnerability
Mirage News: Promising compound kills range of hard-to-treat cancers by targeting previously undiscovered vulnerability
ScienMag: Promising compound kills range of hard-to-treat cancers by targeting a previously undiscovered vulnerability
Ticker Tech: EtiraRx’s Licensed ERX-41 Identified as a Potential New Oral Therapy for Multiple Cancers, Company Prepares for Clinical Trials

EtiraRx’s Licensed ERX-41 Identified as a Potential New Oral Therapy for Multiple Cancers, Company Prepares for Clinical Trials

DALLAS, June 2, 2022 /PRNewswire/ — A scientific team, led by the scientific founders of EtiraRx, has identified a small molecule, ERX-41, as a novel oral therapeutic agent that may have utility in treating multiple solid cancers, including triple negative breast cancer, glioblastoma, ovarian and pancreatic cancers. EtiraRx, headquartered in Biolabs Pegasus Park, plans to initiate clinical trials as early as the first quarter of 2023.

In the work, published in Nature Cancer, the researchers, led by Drs. Jung-Mo Ahn, Ganesh Raj and Ratna Vadlamudi, identified that ERX-41 dramatically enhances endoplasmic reticulum (ER) stress in cancer cells. Since aggressive cancer cells have higher basal levels of ER stress, the enhanced ER stress induced by ERX-41 is not compensated and causes cancer cell death. Normal cells have low basal of ER stress, can compensate for ERX-41 activity and do not undergo cell death after ERX-41 treatment. Using state-of-the-art molecular approaches, the team identified that the molecular target of ERX-41 is the protein encoded by the lysosomal acid lipase A (LIPA) gene and that pharmacologic inhibition of LIPA by ERX-41 enhances ER stress in cancer cells. The study set the foundation for clinical trials with patients with therapy-resistant cancers that are vulnerable to enhanced ER stress.

Said Dr. Raj, “These discoveries are exciting as they represent a novel approach to targeting the Achilles heel of many aggressive cancers- their vulnerability to enhanced ER stress. Our critical finding was that of a new therapeutic target (LIPA) and its undiscovered role in protein folding. By targeting LIPA with ERX-41, protein folding in the cancer cell was disrupted, causing ER stress and promoting cancer cell death. Our findings indicate the potential for an oral agent with a favorable therapeutic index to effectively treat patients with aggressive cancers, for whom options are limited.”

EtiraRx is completing necessary preclinical studies and plans to initiate clinical trials with these compounds, which will take place the first quarter of 2023. Russell Hayward, CEO EtiraRx, said, “ERX-41 has the potential to be a first-in-class oral therapy that kills aggressive therapy-resistant cancers. We are committed to moving these drugs forward to clinical trials and make a difference in the lives of patients with lethal cancers.”

To access the complete paper from EtiraRx, please visit Nature Cancer at  https://www.nature.com/articles/s43018-022-00389-8

About EtiraRx
EtiraRx is a Dallas-based company is committed to developing cures. EtiraRx was founded in 2018 and is headquartered in Pegasus Park.  For more information go to https://www.etirarx.com

Media Contact:
Doug Haslam
Berry & Company Public Relations
dhaslam@berrypr.com